In Vitro Permeability Testing (IVPT)

  • Home
  • In Vitro Permeability Testing (IVPT)

We offer in vitro permeation testing (IVPT) or in vitro skin permeation testing method development, validation and testing services according to FDA testing guidelines. Our IVPT testing focuses around the study of skin percutaneous absorption and the cutaneous pharmacokinetics by the determination and evaluation of permeation amount and rate of active compounds. The same testing can also be applied for studying transdermal permeability and metabolic stability of active compounds as well as effects of other composition changes in formulation. Distribution of active compounds in different skin layers can be also investigated.

Our IVPT services support the following studies:

  • Formulation Development and Optimization
  • Preclinical phase
  • Phases I-III studies
  • Bioequivalence and Bioavailability
  • Toxicology
  • Irritation assessment (safety evaluation of pharmaceutical or cosmetic)

The in vitro skin permeation studies with finite dose has proven to be a valuable tool for the study of percutaneous absorption and the determination of the pharmacokinetics of topically applied drugs. The method has historic precedent for accurately predicting in vivo percutaneous absorption kinetics.

Stira Pharma equipped with Phoenix RDSTM Robotic Diffusion Station  and PermeGear diffusion system.